Eco-Evo Evo-Eco: On retraction

Let’s start by contemplating what retraction is for. They are saying science is ‘self-correcting’, which means new findings get revealed that will contradict and finally eclipse outdated misconceptions. So why can we difficulty retractions in any respect, once we may simply let new papers lead us ahead? I see two distinct motives (there could also be extra, however I feel these are the 2 main principal part axes, so to talk).

1.  Eradicating data from the general public report that we now know to be false. Certain, new papers could later get revealed that appropriate our view. Self-correcting science and all that. However, like an outdated land mine from a forgotten battle, the wrong paper continues to be there for some unwitting reader to stumble throughout and, not realizing concerning the newer work, cite and imagine.

I need to do a little bit of a deep dive into every of those, as a result of every appears easy at first look, however has complexities and caveats as soon as we delve into them. To start out, it helps to acknowledge that we will have considerations about papers for a lot of distinct causes. Certain, there are apparent and egregious instances of fraud the place the information and conclusions are essentially false – duplicated or altered pictures which can be central to the conclusions of the paper, as an illustration. However it may be extra delicate than that, so let’s do one thing analogous to the traditional desk all of us find out about kind I and sort II error in statistics (false optimistic, false unfavourable). The rows of are desk concern validity of the conclusions: a paper can report outcomes which can be factually appropriate, debatable, or incorrect. The columns are concerning the proof, which could be rigorous, flawed/low high quality, or unethical partially, or fraudulent at coronary heart.

Conclusions are:

Rigorous proof

Flawed proof

Unethical partially

Fraudulent at coronary heart


Nice paper!

Proper, however for the improper causes

Fruit of the poisoned tree

Falsifying to achieve a real inference



Debatable & unclear

Dangerous scientist!

Why hassle?


False positives occur.

In good religion.

Trustworthy mistake. Fortunately, science is ‘self-correcting’

Actually dangerous scientist!

Falsifying to achieve a false inference

I will not take the time to contemplate each single permutation, however let’s begin with a case research. On my hike yesterday, my lawyer buddy requested whether or not Charles Darwin’s Origin of Species was appropriate on all factors. Clearly not, I responded. Particularly, Darwin had a deeply incorrect understanding of genetics, that led him astray on just a few factors. We all know higher now. Science being self-correcting and all that. So, my buddy pressed, why do not we ‘retract’ Origin of Species (nevermind that it wasn’t revealed in a journal)? It incorporates errors. We all know that unambiguously. However it’s appropriate in the principle, and of historic worth.

Let’s proceed to a trickier one – Wilhelm Johanssen revealed a paper in The American Naturalist in 1911 expounding the genotype idea of heredity, a revolutionary paper that outlined ‘genotype’ and (to cite a latest historic paper :”the speculation have to be acknowledged as a creation that offered the theoretical foundations or the framework for the upcoming reductionist materials science of genetics, fairly past the notion of its instigator.” However, in the direction of the top of the foundational paper Johanssen makes enjoyable (fairly harshly) of the notion that genes have something to do with chromosomes. 

So, now we now have a traditional paper in a journal (therefore amenable to retraction, not like Origin of Species) that makes a false declare. Ought to we retract it? Effectively, my first intuition is that it’s outdated and a part of the historic report. We make errors in science, and we advance past these errors, and it’s priceless to historians of science to depart our tracks within the sand as we stumble in the direction of (the mirage of?) some reality. There is a authorized concept of a statute of limitations – a time interval past which somebody can’t be charged with an outdated crime. The timeframe varies with the severity of the crime (within the eyes of the regulation), and a few don’t have any such restrict. So is there a statute of limitation on being improper? In that case, how outdated should a paper be to be retraction-proof when proved improper? Nested Clade Evaluation was wildly in style amongst phylogeographers once I was a starting graduate scholar, however we now know the emperor had no garments, and no one makes use of it anymore (I hope). Is that sufficiently old to flee retraction? How outdated is simply too outdated to hassle? The reply relies on the severity of the crime, the tradition and nation. It additionally issues an amazing deal whether or not the motion was unlawful on the time it was dedicated. Immediately the usual is to evaluate previous actions by the modern guidelines of their period.

Or  is it not about age, however intent? Will we tolerate good-faith error? Johanssen had his causes, and reached an inexpensive and trustworthy conclusion by the requirements of the day with the proof out there to him on the time, and we should always not decide him harshly for not realizing what we all know now. Templeton was honest in his need to achieve phylogeographic inferences and on the time we lacked the toolkit for approximate bayesian computation (ABC) strategies that may check complicated biogeographic genetic fashions. He meant effectively, he did the very best he may with the instruments on the time, and if it did not work in addition to he thought, it was trustworthy and well-meaning, and so no retraction is required. As an much more apparent case, I’d got down to check a null speculation with a statistical significance threshold of alpha = 0.05. Like, possibly I need to know whether or not ingesting carbonated water cures COVID (trace – it will not although fortunately its innocent), the null is that carbonated water has no impact on COVID. And as an instance the null is genuinely true (carbonated water will not repair COVID). I do my experiment, and by sheer dangerous luck I’m one of many 5% of such research that discover a P < 0.05, and I publish a paper rejecting the null. I am improper, however I adopted commonplace procedures. Ought to that fictional instance lead to a retraction following different research? Will we usually retract all vital outcomes when subsequent extra highly effective research attain the opposite conclusion? Or vice versa? Presently I feel the usual may be very a lot that errors made in good religion do not warrant penalties no less than. If they’re latest, then a correction is definitely known as for. Possibly even a retraction if the core conclusion is improper. 

I did a retraction because of this myself – a reader famous he could not reproduce a outcome with my information. I appeared again at R code I wrote in 2007 whereas first studying R, and located a one line error based mostly on a misunderstanding of how tails of likelihood distributions had been being reported. It affected the core outcome. So regardless that it was in good religion, I retracted the paper (this was just a few years in the past). Figuring out what I do know now, I may need urged my previous self to a much less knee-jerk excessive response. I used to be pushed by emotional horror. What I should have achieved was to publish a Correction. The info are nonetheless factually legitimate. The query continues to be attention-grabbing. It is simply {that a} optimistic outcome (morphological variations between people impacts weight-reduction plan overlap between them) is now a unfavourable outcome (no, it would not). That is nonetheless a helpful outcome that I might cite, only for completely different causes. This falls into the second column backside row – I had revealed flawed proof for one thing that was false, and I self-reported the flaw.

There is a associated difficult difficulty explicit to idea papers. I am not conscious of many instances (any) of fabricated algebraic options or mannequin outcomes. However there are many instances the place authors made trustworthy errors of their math, stating someplace that x = y when in reality x != y. These could be easy typos made throughout writing (not evaluation). Or, they are often a part of the calculations and, when modified may need little to no impression on the paper’s conclusions, or may radically alter them. The previous clearly benefit correction to the equation, the latter teeter between correction and retraction, relying on the severity of the error. However once more, intent issues right here. It’s simple for math to be demonstrably improper and to show errors, in comparison with information evaluation and experimental designs that may be critiqued however are extra a matter of judgement. But we do not typically retract math errors as a result of corrections suffice and errors made in good religion are usually handled extra leniently. 

So on the entire, I lean in the direction of the private opinion that good-faith errors, whether or not a coding drawback or a random false optimistic or false unfavourable (they occur!), are finest corrected as science builds on previous outcomes, fairly than penalized. Optimistic outcomes is likely to be corrected into Unfavourable outcomes. And as a subject we wish that to be made public freely and brazenly. 

We need to encourage self-correction. When Corrections (and even Retractions) have a robust unfavourable connotation, scientists who discover (or are advised of) an error in their very own work will naturally hesitate to Right or Retract. I certain pressured about it. I should not have. Once I retracted and publicly defined why, I acquired unbelievable optimistic assist from the neighborhood. We wish science to be self-correcting, to extra quickly attain true inferences. If we penalize self-correction, if we put an onus on it, it can occur much less. Individuals reply to incentives. In order for you one thing to be achieved, reward those that do it, not punish them.

Now let’s delve into a gray space: typically scientists gather information and attain a conclusion that’s truly legitimate in actual life. However, the proof that they use to assist their conclusion is flawed. I haven’t got a particular case in thoughts, however hypothetically think about a researcher sequences a inhabitants of fish to search for the presence of a specific allele. It seems their pattern was contaminated, or swapped for one more pattern, so they are not sequencing what they suppose they’re.  However by pleased (?) likelihood, the contamination or improper pattern truly has the allele, as does the inhabitants they suppose they’re sequencing. In order that they appropriately conclude that the allele is current, however they achieve this for a improper cause. That is possibly particularly probably in historical DNA analysis, the place cross-contamination (and absence of DNA in focal samples) is a typical drawback. I like to think about this hypothetical case as a result of it highlights the function of reality / falsehood in our judgements. As an editor or writer, I might be very tempted to retract such a paper, and at a minimal a correction is required. Their revealed report can’t actually show what they declare, as a result of the proof marshaled for it’s essentially irrelevant or incorrect. But, that is achieved totally in good religion, and the end result is factually true.  That is the “Proper however for the improper causes” cell within the grid above. So retraction is not merely about being appropriate or incorrect.  Neither is it merely about malicious fraud / acutely aware deceptive.

Slightly below this within the “Flawed proof column” I put “debatable”. That is for instances the place scientists are possibly tackling a tough topic and the information are merely not definitive. It could be onerous to gather good information and the outcomes could also be ambiguous. The tip outcome may look promising to 1 individual (who favors the thought being examined) however sloppy and unconvincing to a skeptic. That is the stuff that scientific debates are made from. My favourite nowadays is the unnecessarily vitriolic debate over evolutionary impartial (or practically impartial) idea. There are strongly held variations of opinion and all sides genuinely believes the opposite is deeply improper. It is a scientific work in progress,  that  could also be resolved with additional information or idea. It’s undoubtedly not the journal’s job to retract one thing that’s on this debatable class, even when it might finally show to be improper as agreed upon by all events sooner or later. We’re a platform for vigorous knowledgeable debate, not partisans in it. And when the controversy is finally settled, we hold the report of that course of, fairly than deleting the shedding facet through sweeping retractions.

So to recap mid-way, I began by saying one cause to retract is “Eradicating data from the general public report that we now know to be false.” That is interesting and apparent. Besides that we do not often retract issues that we now know to be false, if they’re outdated, or if the error was arrived at in good religion. And typically we’d retract issues which can be truly true, in the event that they had been arrived at for the improper causes. 

Let’s discover this latter level some extra, by contemplating true conclusions reached in dangerous religion. What if a broadcast paper stories a real conclusion, with rigorous legitimate information and enormous pattern sizes (sounds nice, proper?), however having obtained the true information by unethical means. Possibly they did not have a gathering allow to pattern the focal species, or do the experiment within the subject. Possibly they did not have IACUC (animal care) approval, or IRB (human topics) permission? They smuggled permitted-collections overseas? We’re shifting into the “Unethical” column of the desk above. Scientists sadly are typically overeager to do their work and undertake unacceptable strategies. What can we do on this case?  As an Editor (and on the whole as a member of the scientific neighborhood), I feel a paper shouldn’t be accepted for publication if it did not comply with correct authorized and moral procedures. Let’s go along with a problematic hypothetical instance. A researcher discovers a miracle treatment for most cancers. And of their eagerness to check it they skip IRB approval, they skip knowledgeable consent, they administer it to unknowing, non-consenting people… they usually treatment their most cancers. Ought to that paper be revealed? It’s tempting to say, hell sure we wish a treatment for most cancers. However we obtained there by procedures we can’t condone. What to do? One is likely to be tempted to maintain the paper and outcome, however levy some penalty on the researcher. However in the end, it’s the obligation of a journal to retract papers which can be arrived at through unethical means, whatever the validity of the end result. That miracle treatment for most cancers? It’s going to have to attend for another person to copy the preliminary research through moral and permissible means. Meaning a delay in treating folks with most cancers, and lack of life, which feels deeply improper. 

(Word afterwards – one twitter reader famous that if the work was achieved unethically and in secret do we actually belief the outcomes to be true? A good query, however for the aim of exploring this moral conundrum please droop disbelief for a second and settle for that on this fictional state of affairs the precise scientific conclusion is documented rigorously sufficient that we will belief its veracity).

(Word afterwards – due to @SocialImpurity for stating this actual life case that’s related to this moral dilemma)

There’s a captivating analogy right here. In US courts, there’s a authorized metaphor often known as “The fruit of the poisoned tree”. (Word, that is derived from British Widespread Regulation, and isn’t a common doctrine globally). Say there’s a housebreaking. A cop catches an confederate, and with a purpose to discover the ringleader of the gang, tortures the confederate (that is not okay) into revealing the situation of the getaway automobile. Discovering the getaway automobile, which matches the safety movies, and has fingerprints throughout it and the cash hidden beneath the seat, the police determine, seize, and prosecute the ringleader. The nice proof of guilt (the fingerprints on the automobile with the cash) is the product of a nasty course of (torture, the poisoned tree). And the fruit of the poisoned tree is inadmissible in courtroom. Here is the bit that makes many individuals uncomfortable: the thieves go free. Not as a result of they had been harmless. They completely had been responsible. However as a result of the proof of their guilt is the results of a flawed course of. So we throw all of it out. Very like we’d throw out all scientific outcomes (the fruit being the miracle treatment) that come up from the poisoned tree (the IRB human analysis violations). The motive in each instances is to discourage dangerous habits (by scientists, or police) in pursuit of a great end result. The consequence is that good outcomes (most cancers treatment, convicting the responsible) are put aside totally realizing they’re good outcomes. Now, I feel many people get uncomfortable at this outcome, and would argue that the responsible criminals ought to be convicted and the police punished. However, that is not the American & British authorized custom. I ought to be aware that the Fruit of the Poisoned Tree metaphor is strictly about police habits, and has no authorized tooth that reach into different areas like scientific publishing.

Word that the fruit of the poisoned tree doctrine will in all probability make you squirm. I do. I would like to see that miracle treatment made out there. However what moral boundaries are you prepared to waive? Experiments on folks with out consent. That is dangerous. However do the ends justify the means for you? That is the logic (I presume) that drove the syphilis experiments on the Tuskegee Airmen, or Dr. Mengele’s horrific experiments on Jewish focus camp prisoners. Are you prepared to make use of the outcomes of these experiments, prepared to publish them, or allow them to stay on the books? I am not.

However these are excessive instances. Let’s flip the dial of ethical outrage down, and likewise regulate the slider bar away from “most cancers miracle treatment” in the direction of one thing extra life like. Would you publish (or, retract if already revealed) a paper that used stolen archaeological artifacts? Genome sequence information taken from non-consenting people unaware of what their drawn blood was for use for? Presently the expectation is that Editors like myself would reject papers that used ill-gotten samples to achieve a conclusion, whatever the validity of the conclusion. And that commonplace makes no reference to how vital the conclusions are (e.g., an attention-grabbing mental advance, versus the miracle treatment, each are equally topic to this commonplace).

So, hopefully we’re in settlement {that a} scientific outcome (whether or not true or not) arrived at by unethical means will get rejected (and possibly the experiment redone correctly and ethically, if maybe extra slowly). However let’s unpack this some extra and ask what the statute of limitations is right here. How far again does the precept apply? Institutional Evaluate Boards for human topics analysis started in 1974 (see this text for a helpful historical past). Meaning no analysis earlier than 1974 (the yr I used to be born, by the way) was IRB accepted. Immediately we require IRB, so does that imply all journals ought to retract human topics analysis from earlier than 1974? Clearly we do not try this. The important thing distinction is that the pre-1974 papers had been adhering to the moral requirements of their day.

There are different kinds of unethical habits that get caught up in scientific publishing. What constitutes retraction-worthy unethical habits? What if the speaking writer(s) left somebody off the writer record who contributed vital work that might usually be adequate to warrant co-authorship. That is not cool, its not moral, however is it retraction worthy? What in the event that they added an writer who actually did nothing in any respect, merely to achieve credibility by affiliation, or as a bribe for some quid professional quo? Unethical, in each instances. However retraction worthy? Most likely not, partly as a result of it may be onerous for editors to successfully adjudicate who did or didn’t earn the correct to be listed as an writer. And partly as a result of there are different easier treatments – including an writer, or publishing an announcement eradicating an writer.

To push this line of questioning into an much more uncomfortable realm, what if the lead or senior writer on a manuscript, or a broadcast paper, was responsible of sexual assault? Does unethical habits that’s totally decoupled from the paper in query, impression the editorial board’s view of a scientific textual content and conclusion? Ought to we decline to publish, or retract, papers by people whose habits the Editor finds abhorrent? Publishing their paper promotes their identify and function within the scientific neighborhood, and we’d not need to try this. However, the technical conclusions of the paper are (on this hypothetical case) totally unaffected by the authors’ habits. If we open the door to editorial choices based mostly on abhorrent habits, who will get to find out that criterion? One thing that’s abhorrent and unethical to 1 individual is likely to be celebrated by one other (not sexual assault thoughts you, however different types of sexual habits, or political or non secular perception maybe). How a lot proof have to be given to the journal’s Editor to achieve an knowledgeable resolution about whether or not or not the abhorrent habits befell? This explicit difficulty ties me in knots, and I confess I do not know what I might do in such a state of affairs, and am merely glad that it hasn’t come up in my function as Editor dealing with new paper submissions, to my data (I would not be in any respect shocked if some present or previous authors have been responsible of such offenses). What would you do? 

Talking of abhorrent, what about racist and eugenicist analysis of the previous? The American Naturalist has loads of articles by Charles and Gertrude Davenport, leaders on the Chilly Springs Harbor lab for eugenics. Ought to we retract their papers from the 1900’s by 1940’s? Or, one of many first ladies to publish in The American Naturalist wrote a horribly racist rant that’s offensive sufficient that, once I quoted from it in a lecture (to drive house the purpose forcefully and brazenly that AmNat revealed awfully racist stuff), a viewers member subsequently admonished me for exhibiting it. Ought to I am going again and retract that paper, which I suppose I’ve the facility to do as Editor? I would not, just because I feel that might be whitewashing an unpleasant previous that we’re higher off acknowledging and confronting brazenly fairly than making it as if it by no means existed.

We’re virtually achieved, I swear. However I am having enjoyable posing these questions.

The final column in my desk, above, considerations downright fraud.   Picture manipulation. Information alteration or fabrication. Modifications to information or misreporting outcomes with the intent to mislead. The italicized bit could be onerous to show with out mind-reading, so typically we content material ourselves with evaluating whether or not information or a picture are biologically believable. If not, the outcomes are false and information usually are not reliable no matter intent. In impact, we are saying that (not realizing an authors intentions or actions) a paper may both be in the correct hand column (fraud) or the underside row (falsehood), and both one may very well be retracted. In latest instances, choices to retract mirrored patterns in information that look like fraudulent, however we can’t with certainty discern whether or not there was dangerous intent, or just large-scale and recurrent accidents in information administration. The latter appears deeply unlikely, however from the standpoint of journal choices (retract or not) the excellence is irrelevant.

So to recap this second a part of my musings, I began by saying the second cause to retract is “Punishment for misdeeds.” Definitely the ‘Fruit of the Poisoned Tree” doctrine I described represents a punishment, as a result of the scientific conclusions could also be actually true and priceless but we would nonetheless retract – as a penalty and as a deterrent to future scientists contemplating the identical misbehavior to get information. As editors and a neighborhood, we’d stroll away from true data if it was ill-gained. However I expressed discomfort on the considered utilizing retractions as a persist with punish another types of unethical habits. And precise fraud we’d argue that the retraction is for organic falsehood (or lack of reliable proof no less than), fairly than as punishment per se.

Word that I am completely not saying that misbehavior ought to go unpunished. Sexual assault, as an illustration, ought to be prosecuted in courtroom. Sexual harassment as effectively, or on the very least pursued severely and in good religion by the college or establishment the place the harassment befell. What I’m saying although is that punishment is probably not the journal’s main function. The journal serves to speak data, and (to the very best of our talents) to test that the data is sweet. We are able to resolve to cease speaking one thing that we now not belief. However our capability for punishment may be very restricted. At most, I may retract papers from an writer who dedicated systematic fraud. However I would test every paper individually fairly than assume the fraud was common. Maybe I may refuse to contemplate any additional submissions from that writer. However what in the event that they realized their lesson and now pursued an trustworthy and cautious path to new science? Ought to we forgive and overlook (and confirm)? Finally, journals solely have the flexibility to punish utilizing the restricted instruments at their disposal – the papers they publish. It’s the employer (the college, institute) that has the facility to fireside, or reassign duties away from analysis to educating, or placed on unpaid depart, and so on. The employer supplies cash, and cash has a leverage the remainder of us lack.

There’s another excuse why I usually am cautious of utilizing retraction as a type of punishment. I famous earlier that we need to encourage folks to self-correct – that helps clear up our literature sooner. When retractions are systematically equated with punishment, authors who discover errors shall be extra hesitant to self-retract. One resolution can be a linguistic one – if we adopted two completely different phrases for 2 completely different sorts of retraction. Honorable self-correcting retraction, and dishonorable retraction for fraud or unethical habits. Name them subtraction and detraction, respectively (I am open to options). However I feel it’s essential that we punish, and essential additionally that we reward trustworthy self-correction. These should be saved separate within the sociology of science.


So, again to my authentic premise: when is it acceptable to retract?

Are we eradicating data from the general public report that we now know to be false? Are we punishing? The reply is delicate, as a result of we do not need to conflate punishment with retraction. As a result of journals have the facility to retract however restricted energy to punish, which is healthier achieved by employers (who journals can and may notify). As a result of we typically retract issues which can be true (fruit of the poisoned tree) however typically do not retract issues which can be false (in good religion, or outdated). 

This subtlety is made much more difficult by a complete different set of questions: is the false or fraudulent data central, or peripheral, to the conclusions of the paper in query? Clearly if the first level of a paper seems to be essentially incorrect (as in my very own retraction for a coding error), retraction is a good end result. However what if it’s a minor apart? For example Matt Daemon describes an in depth experiment on how the proportion of feces in dust impacts plant development on Mars. And he says within the paper that he was sporting a blue area swimsuit when actually it was inexperienced. That is a falsehood, however irrelevant to the biology. It ought to be corrected, however has no bearing on the conclusions. Or, he falsely stories that feces helped develop potatoes on Mars, then builds and obtains analytical options for a set of atypical differential equations that appropriately set up that nutrient addition would assist. The maths is true. Do you retract it? Doing so can be leveling accusations at an harmless equation by assuming guilt-by-association.

The very last thing I need to touch upon is the function of the journal, and those that volunteer time for it, in publicizing retractions. If the purpose of a retraction is to appropriate one thing we now know is fake, we should attain out to individuals who beforehand learn the paper and notify them of the retraction. In any other case, they are going to proceed to carry a false perception based mostly on their authentic studying of the paper earlier than retraction. Furtive retraction isn’t any retraction in any respect. And, if the purpose of a retraction is punishment (which, once more, isn’t my core perception), once more the punishment has probably the most impression whether it is public. Both manner, retractions should be clearly conveyed with the unique paper on the journal web site, with corresponding adjustments to Jstor, PubMed, Google Scholar, and so on. Utilizing social media to disseminate the actual fact of a retraction is totally cheap as a method to connect with readers who use that channel. The downside of social media after all is the convenience with which it ideas into private fairly than skilled. However any process that disseminates the announcement of 1 (or extra) retractions will invite gossip, hypothesis, extrapolation, and private judgements, particularly when misconduct (or the sturdy suspicion thereof) is concerned. 

The opposite attention-grabbing facet of social media dissemination of Correction / Retraction choices, is that it invitations armchair editors to inveigh. I have been known as a “coward” and “lazy” on social media for a choice to difficulty a Correction fairly than Retraction, by somebody who did not know the paper, hadn’t learn it, did not perceive the negligible function that the information performed, or the character of the mannequin being reported (not parameterized with or testing information). If there’s one factor I hope the essay above has taught, is that retraction and correction span a various set of complicated concerns. There are concerns of scientific truth or error. These could also be central or peripheral to the paper. They could be reached by moral or unethical means. They could be outdated errors or new ones, passable by the requirements of their day however not as we speak. And every of those dimensions is a continuum starting from totally-fine to absolutely-bad with gray areas in between. Generally, questions of fraud or retraction are unambiguous. Editors ought to interact totally with these and do the correct factor. However challenges to papers also can fall into gray areas, or be good by one criterion and dangerous by one other. The Editor’s difficult job (supported by their editorial board and reviewers in session with authors) is to achieve a ultimate judgement. These are, in my expertise, typically simple and typically onerous. So, if an Editor merely ignores critiques, that is dangerous. But when they do not act precisely the best way you prefer to, take into account that they’re weighing many themes and should have a justifiable (not essentially cowardly / lazy) rationale for his or her resolution.

Because of J. Shukla for uplifting dialog.

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